By Steve Webber, Jan-Anders Karlsson (auth.), Dr. David Raeburn, Dr. Mark A. Giembycz (eds.)
Building at the current titles within the "Airways soft Muscle" sub-series, the 6th quantity explores physiological and pharmacological techniques within the lung in vivo. a few of the animal types to be had for learning the bronchospasm and irritation linked to human bronchial asthma are completely reviewed via across the world recognized scientists. particular chapters specialise in the issues of administering medicinal drugs to animal airlines, the mechanics of assessing lung functionality within the types, and describe intimately the species used, from rodents to primates. using genetically altered animals, a space of specific curiosity to molecular biologists, is usually thought of intensive. This updated and largely referenced paintings will turn out useful to pharmacologists, physiologists and different organic scientists in any respect degrees in academia and within the pharmaceutical industry.
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Additional info for Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo
Respir Physiol 1980; 40: 65-78. 24. Griffiths-Johnson DA, Nicholls PJ, McDermott M. Measurement of specific airway conductance in guinea pigs. J. Pharmacol Methods 1988; 19: 233-42. 25. Dennis MW, Douglas JS, Casby JU, Stolwijk JAJ, Bouhuys A. On-line analogue computer for dynamic lung compliance and pulmonary resistance. J Appl Physiol 1969; 26: 248-52. 26. Mead J. Control of respiratory frequency. J Appl Physiol 1960; 15: 325-36. 27. Murphy SD, Ulrich CE. Multi-animal test system for measuring effects of irritant gases and vapors on respiratory function of guinea pigs.
Gravitational sedimentation accounts in part for the deposition of smaller particles in the deeper airways and the alveoli where air velocity is low and residence time is longer. 8 11m, the possibility of particles diffusing into contact with the airway wall in bronchioles and alveoli is increased by Brownian motion and diffusion becomes the primary factor in deposition . However, aerosols normally contain only a small fraction of particles in this size range . Generally, particles smaller than 5 11m are regarded as in the respirable range for humans .
J Pharrnaco1 Exp Ther 1987; 242: 450-4. Gupta P, Markham A, Morgan RM. Ca 2 + ion sequestration by guinea pig tracheal cartilage: its influence on tracheal reactivity to KCI. Br J Pharmaco1 1991; 104: 123-7. Jiang HE, Stephens NL. Contracti1e properties of bronchial smooth muscJe with and without cartilage. J Appl Physiol 1990; 69: 120-6. Goodman FR, Weiss GB, Sturm B. Comparison of 45Ca binding and mobilization in cartilage and smooth muscle of guinea pig trachea. Fed Proc 1986; 45: 324. Goodman FR, Weiss GB, Karaki H, Nakagawa H.
Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo by Steve Webber, Jan-Anders Karlsson (auth.), Dr. David Raeburn, Dr. Mark A. Giembycz (eds.)