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New PDF release: Archie Comics 157 (August 1965)

By Richard H. Goldwater, Frank Doyle, Joe Edwards, Sy Reit, Samm Schwartz

Archie Comics #157 - August 1965

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Extra resources for Archie Comics 157 (August 1965)

Sample text

The first class identified 21 was the ligand-gated chloride channels, including those of the GABAA and glycine receptors. The ligand-gated chloride channels are common in dorsal horn neurons. The second class, also likely common spinal levels, is the voltage-gated chloride channels. The final chloride channel class is activated by cyclic adenosine monophosphate and may include only the cystic fibrosis transmembrane regulator. Activation of chloride currents usually produces inward movement of chloride to cells that hyperpolarize neurons; facilitation of these hyperpolarizing currents underlies the mechanisms of many depressant drugs.

75. (C) Nitric oxide is released in response to NMDA receptor activation and is implicated in neuronal plasticity rather than antinociception. Amongst the substances found in the descending inhibitory pathways of the CNS are norepinephrine and serotonin. 76. (D) The Ca2+ channel can be divided into subtypes according to electrophysiological characteristics, and each subtype has its own gene. The L-type Ca2+ channel is the target of a large number of clinically important drugs, especially dihydropyridine, and binding sites of Ca2+ antagonists have been clarified.

58. (E) Voltage-gated sodium channels underlie the electrical excitability demonstrated by mammalian nerve and muscle. Nine voltagegated sodium channels are expressed in complex patterns in mammalian nerve and muscle. Six have been identified in the DRG. 9, are expressed selectively in peripheral damagesensing neurons. 8 seems to play a specialized role in pain pathways. 59. (A) The nonopioid analgesic ziconotide has been developed as a new treatment for patients with severe chronic pain who are intolerant of and/or refractory to other analgesic therapies.

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Archie Comics 157 (August 1965) by Richard H. Goldwater, Frank Doyle, Joe Edwards, Sy Reit, Samm Schwartz


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