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Read e-book online Cholecystokinin and Anxiety: From Neuron to Behavior PDF

By Jacques Bradwejn M.D., F.R.C.P.C., Eero Vasar M.D., Ph.D. (auth.)

ISBN-10: 3662217058

ISBN-13: 9783662217054

ISBN-10: 3662217074

ISBN-13: 9783662217078

This booklet is set the position of cholecystokinin (CCK) within the neurobiology of hysteria and panic assaults. An updated assessment of the subject is given in a multidisciplinary viewpoint starting from neurochemistry to human habit. This quantity is both informative to uncomplicated and scientific scientists.

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Additional resources for Cholecystokinin and Anxiety: From Neuron to Behavior

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Rajkowski J, Kubiak P, Aston-Jones G. Activity of locus ceruleus neurones in behaving monkeys varies with focused attention: short- and long-term changes. Soc Neurosci Abstr 1992; 18:538. 30. Woods SW, Charney DS. Biological responses to panic anxiety elicited by nonpharmacologic means. In: Ballenger JC, ed. Neurobiology of panic disorder. New York: Wiley-Liss, 1990:205-217. 31. Ko GN, Elsworth JD, Roth RH et al. Panic-induced elevation of plasma MHPG levels in phobic-anxious patients: effects of clonidine and imipramine.

7_ Schematic illustration of the biosynthesis cholecystokinin in neurons. The structure of preprocholecystokinin is illustrated as the bar in the upper part of the figure. 38 Cholecystokinin and Anxiety: from Neuron to Behavior the single precursor for the two enzymes necessary for amidation. 4649 These enzymes remove glyoxylate from the immediate precursors, the glycine-extended CCKs, to complete the synthesis of bioactive a-carboxyamidated peptides (Fig. 1). As a result of the elaborate biosynthetic pathway, CCK neurons release a heterogeneous mixture of proCCK products from the mature vesicles.

Schmauss M, Laakman G, Dieterle D. 2-receptor blockade in addition to tricyclic antidepressants in therapy-resistant depression. J Clin Psychopharmacol 1988; 8:108-111. 18. Papp LA, Klein DF, Gorman JM. Carbon dioxide hypersensitivity, hyperventilation and panic disorder. Am J Psychiatry 1993; 150:1149-1157. 19. Gorman JM, Goetz RR, Dillon D. Sodium D-lactate infusion in panic disorder patients. Neuropsychopharmacol 1990; 3:181-189. 20. Anderson WC, Wetzler S. Five percent carbon dioxide challenge: valid analogue and marker of panic disorder?

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Cholecystokinin and Anxiety: From Neuron to Behavior by Jacques Bradwejn M.D., F.R.C.P.C., Eero Vasar M.D., Ph.D. (auth.)


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