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Roy Hertz (auth.), Sheldon J. Segal (eds.)'s Chorionic Gonadotropin PDF

By Roy Hertz (auth.), Sheldon J. Segal (eds.)

ISBN-10: 1468410628

ISBN-13: 9781468410624

ISBN-10: 1468410644

ISBN-13: 9781468410648

This quantity is dedicated to the chemistry, immunology, molecular biology, and body structure of the human chorionic gonadotropin, heG. For this glycoprotein molecule the direction from discovery to chemical decoding coated approximately fifty years. It used to be in 1928 that Ascheim and Zondek suggested that urine from pregnant girls comprises whatever that stimulates the ovaries of mice or rats. This supplied the root for the recognized A-Z attempt for being pregnant and for the "rabbit attempt" amendment brought by means of Friedman. As researchers sought to discover extra delicate responses to heG, they used a wide selection of species together with the South African aquatic toad, Xenopus Zaevis, the terrestrial toad of South the US, Bufo arinarus, and the African weaver finch, EupZeetes afra. The weaver finch feather response was once rather noteworthy, for it disclosed a non-gonadal reaction to heG/LH. looking back, this can were an immense evolutionary clue to the belief that the designation of the hormone as a "gonadotropin" could have been simply in part descriptive of the molecule's physiological function--a idea that is gaining consciousness, because the papers during this 1980 quantity divulge.

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8:48. Matthies, D. , 1967, Studies on the luteotropic and mammotropic factor found in trophoblast and maternal peripheral blood of the rat at mid-pregnancy, Anat. Rec. 159:55. , 1929, On the presence of a myogenic substance in the mouse placenta, Proc. Roy. Soc. (Edinburgh) 50:104. , Glass, L. , and Page, E. , 1966, Studies of induced malignant tumors of placental and uterine origin in the rat, Am. J. Obstet. Gynecol. 95:559. , Connell, K. G•• and Passantino. ) 256:739. , Supp1. 142:207. , and Hobson, B.

385-398. , and Weintraub, B. , 1979, Thyrotropin receptors on bovine thyroid membranes: Two types with different affinities and specificities, Endocrinology 105:352. Rifkind, A. , Canfield, R. , 1976, Inhibition chemical induction of porphyrin synthesis in chick embryo liver cells by partially purified human chorionic gonadotropin, Biochem. Biophys. Res. Commun. 68:503. , 1978, Effect of chorionic gonadotropin on human thyroid tissue in vitro, J. Clin. Endocrinol. Metab. 46:420. Simpson, M. , C.

0 Kgy Figure 4. 001 of a placenta, chromatographed on Sephadex G-200. Each fraction was assayed in hCG, hCGa, and hCGS RIAs. The position for human serum albumin (HSA) is indicated. regarded as a waste product with a majority of molecules not identical to those circulating in the body or present in the placenta. Extracts of rat placentae were treated with 8 and 10 M urea for 2 hr at 37°C and after that chromatographed on a Sephadex G-25 column. After urea treatment, there were significant increases in both CGa and CGS activities, and a decrease in the CG activity.

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Chorionic Gonadotropin by Roy Hertz (auth.), Sheldon J. Segal (eds.)

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